Celiac Disease – medical explanation

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Celiac disease is an inflammatory disorder of the small intestine caused by the ingestion of gluten, which is installed in individuals genetically susceptible in terms of making that maladies.

Inflammation can cause absorption of several important nutrients. Recovery Clinical and mucous recovery after the imposition of a strict diet, gluten-free, is an obvious proof of the fact that enteropathy is caused by the ingestion of gluten. In 1950, Dicke WK. Coeliakie. PhD thesis noted the essential role of gluten in disease pathogens celiac. This disease is directly related dermatitis herpetologist dermatitis herpetologist. Typical manifestations take the form of rash and osteopathy of the small intestine, similar devices within celiac disease and gluten removing both symptoms respond to the diet.

Methods.

The study is based on the communications exposed in the international symposiums 3-7 on meetings and discussions on celiac disease, the books and documentation articles in Medline (only in 1997 were published 250 articles).

Symptoms and signs.

Associated sometimes with untreated celiac disease, certain signs and symptoms can be divided into intestinal manifestations and events generated by mal-absorbtion. It should be emphasized, however, that many patients – especially adults – minimal symptoms. Intestinal symptoms are sometimes absent in adults with celiac disease, but in many cases, clinically, can meet ulcers, dyspepsia, abdominal bleeding manifestations occur in some patients diarrhea. Products absorption such as anemia or osteoporosis, while others prevalent disorders associated with celiac disease – a classic example is dermatitis herpetiformis, manifested by a vesicular rash.

Epidemiology.

With a decade ago, celiac disease was considered a less encountered, the prevalence rates were 1 in 1,000 or even canceled. However, a number of population studies have shown a higher prevalence and currently it is estimated that celiac disease can affect an individual in 200.  According to the model cited was clinically diagnosed only a small number of individuals, which may explain the low prevalence figures, previously reported. Instead, most people experience a so-called hidden celiac disease, which can remain undiagnosed because they do not show clinical manifestations.

The result according to which the prevalence of celiac disease is a disorder can be attributed judicious use of serological screening tests that measure antibody titer antiendomisiali and those antigliadina of the tests mentioned at determining endemically antibodies to diagnose celiac disease contributed due to the specificity and its very high sensibility. Continue performing screening at the population level should provide additional data on the prevalence of celiac disease in the mondial plan. For example, based on positive results in tests for determination of antibodies is likely that the disease Celiac be a condition encountered more frequently than it initially considered Unite States.

Celiac disease can occur at any age, but incidence in adults headed maximum is reached after 50 years of older. Women are affected to a greater extent than men and in patients who are at the age of fertility was observed compared women. Although celiac disease is correlated closely with childhood, several very recent studies show that the disease is encountered increasingly rarer to children. Factors responsible for this change are controversial. One explanation lies in the exclusion of gluten from the diet of infants, common practice in many countries after 1970. Another hypothesis would be that children prone to this disease will have such manifestations of celiac later, in life after exposure risk factors accordingly.

Associated Diseases.

It is not known what triggers the increased prevalence of celiac disease and, although they were made a series of correlations between this disease and others, is possible that in many cases these associations have been merely accidental. However, the latest studies of screening have shown an increased prevalence of celiac disease in certain conditions, as this type of diabetes and thyroid disease autoimmune. The finding may be true for other autoimmune disorders of origin – for example, primary biliary cirrhosis. Such an association may be explained by either a common genetic background, as is the case in particular HLA gene type, 23 is similar mechanisms of diseases mediated by the immune system. This HLA a similar haplotype is likely to be partly explained by strong correlation between IgA deficiency and celiac disease proved by a high prevalence in patients with osteoporosis. In other cases appear unusual combinations, such as epilepsy and different neurological conditions.

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